Researchers have gained a new insight into the spinal injury seen in spinal muscular atrophy.
A team from the University of Missouri identified the communication breakdown between nerves and muscles in mice with an animal model of the condition.
Michael Garcia, associate professor, explained that critical communication takes place at the point where nerves and muscles 'talk' to each other.
However, if this communication is faulty, the muscles do not work properly.
"In this study, we found that delivery of ‘the words’ a nerve uses to communicate with muscles was disrupted before they arrived at the nerve ending," he said.
This finding could lead to treatments for other motor neuron diseases including amyotrophic lateral sclerosis (ALS), and conditions involving dysfunctions of the synapses, such as Duchenne Muscular Dystrophy.
In other news, new stem cell technology could be used to protect against neurodegenerative disorders such as ALS, researchers at Tel Aviv University have reported.
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Posted by Paul Breen
